For research use only. Not for therapeutic Use.
Lydicamycin（Cat No.:M117456）is a high-purity antibiotic belonging to the macrolactam class, known for its potent activity against Gram-positive bacteria, including drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). It disrupts bacterial protein synthesis by targeting the ribosome, making it a valuable tool in antimicrobial research. Lydicamycin is widely studied for its unique mechanism of action and potential in developing new therapeutic strategies to combat antibiotic resistance. Its specificity and robust activity make it an essential compound for advancing microbiological studies and pharmaceutical drug discovery efforts.
| Catalog Number | M117456 |
| CAS Number | 133352-27-9 |
| Synonyms | lydicamycin |
| Molecular Formula | C47H74N4O10 |
| Purity | ≥95% |
| Target | Antibiotic |
| Storage | -20°C |
| IUPAC Name | 2-[21-[1-[(2,4-dioxopyrrolidin-3-ylidene)-hydroxymethyl]-5,6-dihydroxy-1,3-dimethyl-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-2-yl]-2,6,10,14,18-pentahydroxy-5,11,17,19-tetramethylhenicosa-4,8,12,16-tetraenyl]pyrrolidine-1-carboximidamide |
| InChI | InChI=1S/C47H74N4O10/c1-26(37(54)10-7-11-38(55)27(2)13-18-33(53)24-31-9-8-22-51(31)46(48)49)12-16-32(52)17-14-28(3)42(58)29(4)15-19-35-30(5)23-34-36(20-21-39(56)43(34)59)47(35,6)44(60)41-40(57)25-50-45(41)61/h7,10,12-14,16,23,26,29,31-39,42-43,52-56,58-60H,8-9,11,15,17-22,24-25H2,1-6H3,(H3,48,49)(H,50,61) |
| InChIKey | HNSRCWWMQWCNGW-UHFFFAOYSA-N |
| SMILES | CC1=CC2C(CCC(C2O)O)C(C1CCC(C)C(C(=CCC(C=CC(C)C(C=CCC(C(=CCC(CC3CCCN3C(=N)N)O)C)O)O)O)C)O)(C)C(=C4C(=O)CNC4=O)O |
| Reference | TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598. Furumai T. et al. J. Antibiot. 2002, 55, 873.<br/><br/>A new neuritogenetic compound BU-4514N produced by Microtetraspora sp.. Toda S. et al. J Antibiot. 1993, 46, 875.<br/><br/>Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity. Hayakawa Y. et al. J Antibiot. 1991, 44, 282.<br/><br/>Lydicamycin, a new antibiotic of a novel skeletal type. II. Physico-chemical properties and structure elucidation. Hayakawa Y. et al. J Antibiot. 1991, 44, 288.</span></p> |
