For research use only. Not for therapeutic Use.
LYG-202, a flavonoid, has potent anti-angiogenic and antitumor activity. LYG-202 inhibits VEGF-stimulated HUVEC migration and tube formation. LYG-202 induces cancer cell apoptosis[1][2].
| Catalog Number | R067077 |
| CAS Number | 1175077-25-4 |
| Synonyms | 5-hydroxy-8-methoxy-7-[4-(4-methylpiperazin-1-yl)butoxy]-2-phenylchromen-4-one |
| Molecular Formula | C25H30N2O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H30N2O5/c1-26-11-13-27(14-12-26)10-6-7-15-31-22-17-20(29)23-19(28)16-21(18-8-4-3-5-9-18)32-25(23)24(22)30-2/h3-5,8-9,16-17,29H,6-7,10-15H2,1-2H3 |
| InChIKey | ICGYSEWPMDWBIL-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)CCCCOC2=C(C3=C(C(=C2)O)C(=O)C=C(O3)C4=CC=CC=C4)OC |
| Reference | [1]. Chen Y, et al. LYG-202, a newly synthesized flavonoid, exhibits potent anti-angiogenic activity in vitro and in vivo. J Pharmacol Sci. 2010;112(1):37-45. [2]. Zhao Y, et al. LYG-202 exerts antitumor effect on PI3K/Akt signaling pathway in human breast cancer cells. Apoptosis. 2015 Sep;20(9):1253-69. |
