LYN-1604 dihydrochloride

• CAT Number: I015600
• CAS Number: 2310109-38-5
• Molecular Formula: C₃₃H₄₅Cl₄N₃O₂
• Molecular Weight: 657.54
• Purity: ≥95%
• Target: Apoptosis
• IUPAC Name: 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(naphthalen-2-ylmethoxy)ethyl]piperazin-1-yl]ethanone;dihydrochloride
• InChI: 1S/C33H43Cl2N3O2.2ClH/c1-24(2)19-37(20-25(3)4)22-33(39)38-15-13-36(14-16-38)21-32(30-12-11-29(34)18-31(30)35)40-23-26-9-10-27-7-5-6-8-28(27)17-26;;/h5-12,17-18,24-25,32H,13-16,19-23H2,1-4H3;2*1H
• InChIKey: GZCBLOPFZPJUOQ-UHFFFAOYSA-N
• SMILES: CC(C)CN(CC(C)C)CC(=O)N1CCN(CC1)CC(C2=C(C=C(C=C2)Cl)Cl)OCC3=CC4=CC=CC=C4C=C3.Cl.Cl

LYN-1604 dihydrochloride (CAT: I015600) is a potent activator of UNC-51-like kinase 1 (ULK1) with potential applications in the research of triple-negative breast cancer (TNBC). LYN-1604 activates ULK1, exhibiting enzymatic activity and affinity for wild-type ULK1. It induces cell death, up-regulates Beclin-1, and promotes autophagy through the ULK complex in MDA-MB-231 cells. LYN-1604 also increases the cleavage of caspase 3, leading to apoptosis. In preclinical models of TNBC xenografts, LYN-1604 inhibits tumor growth by targeting ULK1-mediated cell death. These findings suggest LYN-1604 is a promising compound for further investigation in TNBC therapy.