LYN-1604

• CAT Number: I020352
• CAS Number: 2088939-99-3
• Molecular Formula: C33H45Cl4N3O2
• Molecular Weight: 657.54
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CC(C)CN(CC(C)C)CC(=O)N1CCN(CC1)CC(C2=C(C=C(C=C2)Cl)Cl)OCC3=CC4=CC=CC=C4C=C3

LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.

Reference

[1] Zhang L, et al. Chem Sci. 2017, 8(4):2687-2701.