LYP-IN-1

• CAT Number: I031271
• CAS Number: 1404436-51-6
• Molecular Formula: C28H20ClNO6
• Molecular Weight: 501.92
• Purity: 98%
• Synonyms: LYP-IN-1
• Target: Metabolic Enzyme/Protease
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-((3-chlorophenyl)ethynyl)-2-(4-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-6-hydroxybenzofuran-5-carboxylic acid
• InChI: InChI=1S/C28H20ClNO6/c29-18-3-1-2-16(12-18)4-11-21-22-13-23(28(33)34)24(31)14-25(22)36-27(21)17-5-9-20(10-6-17)35-15-26(32)30-19-7-8-19/h1-3,5-6,9-10,12-14,19,31H,7-8,15H2,(H,30,32)(H,33,34)
• InChIKey: IIURSEJMCKFEQG-UHFFFAOYSA-N
• SMILES: O=C(O)C1=C(O)C=C(OC(C2=CC=C(OCC(NC3CC3)=O)C=C2)=C4C#CC5=CC=CC(Cl)=C5)C4=C1

LYP-IN-1(CAT: I031271) is a potent, selective, and specific inhibitor of lymphoid tyrosine phosphatase (LYP), a critical regulator of T-cell receptor signaling. It also exhibits selectivity for other protein tyrosine phosphatases (PTPs), including SHP1 and SHP2. By modulating these pathways, LYP-IN-1 is particularly valuable in immunology research for studying autoimmune disorders such as rheumatoid arthritis and lupus. Its ability to influence immune cell activation and signaling provides a promising avenue for exploring targeted therapies aimed at restoring immune balance and mitigating autoimmune disease progression.