For research use only. Not for therapeutic Use.
LYP-IN-1 is a potent, selective and specific LYP inhibitor. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 and SHP2. It can be used in study of autoimmune disorders.
| Catalog Number | I031271 |
| CAS Number | 1404436-51-6 |
| Synonyms | LYP-IN-1 |
| Molecular Formula | C28H20ClNO6 |
| Purity | 98% |
| Target | Metabolic Enzyme/Protease |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 3-((3-chlorophenyl)ethynyl)-2-(4-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-6-hydroxybenzofuran-5-carboxylic acid |
| InChI | InChI=1S/C28H20ClNO6/c29-18-3-1-2-16(12-18)4-11-21-22-13-23(28(33)34)24(31)14-25(22)36-27(21)17-5-9-20(10-6-17)35-15-26(32)30-19-7-8-19/h1-3,5-6,9-10,12-14,19,31H,7-8,15H2,(H,30,32)(H,33,34) |
| InChIKey | IIURSEJMCKFEQG-UHFFFAOYSA-N |
| SMILES | O=C(O)C1=C(O)C=C(OC(C2=CC=C(OCC(NC3CC3)=O)C=C2)=C4C#CC5=CC=CC(Cl)=C5)C4=C1 |
| Reference | 1: He Y, Liu S, Menon A, et al. A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. J Med Chem. 2013;56(12):4990‐5008. doi:10.1021/jm400248c |
