LYPLAL1-IN-1

• CAT Number: I018727
• CAS Number: 1966129-74-7
• Molecular Formula: C₂₉H₂₉N₇O₄
• Molecular Weight: 539.59
• Purity: ≥95%
• IUPAC Name: (2R,3R)-1-[3-[4-(2-morpholin-4-ylpyrimidin-5-yl)phenyl]-1,2,4-triazole-1-carbonyl]-2-phenylpiperidine-3-carboxylic acid
• InChI: InChI=1S/C29H29N7O4/c37-27(38)24-7-4-12-35(25(24)21-5-2-1-3-6-21)29(39)36-19-32-26(33-36)22-10-8-20(9-11-22)23-17-30-28(31-18-23)34-13-15-40-16-14-34/h1-3,5-6,8-11,17-19,24-25H,4,7,12-16H2,(H,37,38)/t24-,25+/m1/s1
• InChIKey: OWBNMAVVNDAXQY-RPBOFIJWSA-N
• SMILES: C1C[C@H]([C@@H](N(C1)C(=O)N2C=NC(=N2)C3=CC=C(C=C3)C4=CN=C(N=C4)N5CCOCC5)C6=CC=CC=C6)C(=O)O

LYPLAL1-IN-1（Cat No.:I018727）is an investigational small molecule inhibitor targeting the enzyme LYPLAL1 (lysophospholipase-like 1), which is involved in lipid metabolism. LYPLAL1 plays a role in the breakdown of lysophospholipids, molecules that are important in cell signaling and membrane dynamics. By inhibiting LYPLAL1, LYPLAL1-IN-1 is being studied for its potential therapeutic effects in conditions related to lipid dysregulation, such as metabolic disorders and certain types of cancer. Preclinical studies suggest it could modulate lipid metabolism pathways, but further research and clinical trials are needed to evaluate its safety and efficacy in humans.

Reference

[1]. Ahn K, et al. Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism. ACS Chem Biol. 2016 Sep 16;11(9):2529-40.