For research use only. Not for therapeutic Use.
Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta[1][2].
Lys-D-Pro-Thr (10 mg/kg; IP; for 4 days) inhibits the protective effect of fMLP (HY-P0224) and that of MMK-1 (HY-P1117) against Etoposide (HY-13629)-induced alopecia[1].
| Catalog Number | M022107 |
| CAS Number | 117027-34-6 |
| Synonyms | (2S,3R)-2-[[(2R)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid |
| Molecular Formula | C15H28N4O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H28N4O5/c1-9(20)12(15(23)24)18-13(21)11-6-4-8-19(11)14(22)10(17)5-2-3-7-16/h9-12,20H,2-8,16-17H2,1H3,(H,18,21)(H,23,24)/t9-,10+,11-,12+/m1/s1 |
| InChIKey | LOGFVTREOLYCPF-KXNHARMFSA-N |
| SMILES | CC(C(C(=O)O)NC(=O)C1CCCN1C(=O)C(CCCCN)N)O |
| Reference | [1]. Takahiro Tsuruki, et al. Mechanism of the protective effect of intraperitoneally administered agonists for formyl peptide receptors against chemotherapy-induced alopecia. Biosci Biotechnol Biochem. 2007 May;71(5):1198-202. [2]. Y Uehara, et al. Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats. Neuropeptides. 1991 May;19(1):9-11. |
