Lysine clofibrate

• CAT Number: I031295
• CAS Number: 77111-08-1
• Molecular Formula: C16H25ClN2O5
• Molecular Weight: 360.84
• Purity: 98%
• Synonyms: Lysine clofibrate
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: L-Lysine, 2-(4-chlorophenoxy)-2-methylpropanoate
• InChI: InChI=1S/C10H11ClO3.C6H14N2O2/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8;7-4-2-1-3-5(8)6(9)10/h3-6H,1-2H3,(H,12,13);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1
• InChIKey: GICOKXUAIACRIF-ZSCHJXSPSA-N
• SMILES: N[C@@H](CCCCN)C(O)=O.CC(C)(OC1=CC=C(Cl)C=C1)C(O)=O

Lysine clofibrate (Cat No.: I031295) is a lysine salt form of clofibric acid, a lipid-lowering agent belonging to the fibrate class. It functions primarily as a peroxisome proliferator-activated receptor alpha (PPARα) agonist, promoting the catabolism of triglyceride-rich lipoproteins and increasing HDL cholesterol levels. Lysine clofibrate improves lipid metabolism and is used in the management of hyperlipidemia and related cardiovascular conditions. Its enhanced water solubility compared to clofibric acid improves absorption and bioavailability, making it useful in clinical and pharmaceutical research.

Reference

1: de Aguiar Magano L. [Clinical and therapeutic evaluation of a new antilipemic substance]. Arch Sci Med (Torino). 1980 Jan-Mar;137(1):131-9. Italian. PubMed PMID: 7458646.