Lysipressin Acetate

• CAT Number: I031316
• Molecular Formula: C48H68N12O15S2
• Molecular Weight: 1117.261
• Purity: 98%
• Synonyms: Lysipressin Acetate. L-Lysine vasopressin; Lypressin; Lysine pitressin; Lysine vasopressin; Lysine-ADH; Lysopressin; Lysylvasopressin; Oxytocin, 3-(L-phenylalanine)-8-L-lysine-; Postacton; Syntopressin; Vasophysin; Vasopressin-8-lysine; [8-Lysine]Vasopressin.
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond).
• InChI: InChI=1S/C46H64N12O13S2.C2H4O2/c47-17-5-4-9-29(40(65)51-22-38(62)63)53-45(70)35-10-6-18-58(35)46(71)34-24-73-72-23-28(48)39(64)54-31(20-26-11-13-27(59)14-12-26)43(68)55-32(19-25-7-2-1-3-8-25)42(67)52-30(15-16-36(49)60)41(66)56-33(21-37(50)61)44(69)57-34;1-2(3)4/h1-3,7-8,11-14,28-35,59H,4-6,9-10,15-24,47-48H2,(H2,49,60)(H2,50,61)(H,51,65)(H,52,67)(H,53,70)(H,54,64)(H,55,68)(H,56,66)(H,57,69)(H,62,63);1H3,(H,3,4)/t28-,29-,30-,31-,32-,33-,34-,35-;/m0./s1
• InChIKey: MSNBBKCTGMZLMA-DHSVNZEYSA-N
• SMILES: O=C([C@@H](N)CSSC[C@H](NC1=O)C(N2[C@H](C(N[C@H](C(NCC(O)=O)=O)CCCCN)=O)CCC2)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CC(N)=O)=O)CCC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4.CC(O)=O

Lysipressin Acetate is an analog of Vasopressin, a powerful vasopressor used to modulate blood pressure. An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action.

Reference

1: Rouille Y, Chauvet MT, Chauvet J, Acher R, Hadley ME. The distribution of lysine vasopressin (lysipressin) in placental mammals: a reinvestigation of the Hippopotamidae (Hippopotamus amphibius) and Tayassuidae (Tayassu angulatus) families. Gen Comp Endocrinol. 1988 Sep;71(3):475-83. PubMed PMID: 3192070.
2: Acher R, Chauvet J. Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors. Biochimie. 1988 Sep;70(9):1197-207. Review. PubMed PMID: 3147712.
3: Rouillé Y, Chauvet MT, Chauvet J, Acher R. Dual duplication of neurohypophysial hormones in an Australian marsupial: mesotocin, oxytocin, lysine vasopressin and arginine vasopressin in a single gland of the northern bandicoot (Isoodon macrourus). Biochem Biophys Res Commun. 1988 Jul 15;154(1):346-50. PubMed PMID: 3395337.
4: Chauvet J, Rouille Y, Chauvet MT, Acher R. Evolution of marsupials traced by their neurohypophyseal hormones: microidentification of mesotocin and arginine vasopressin in two Australian families, Dasyuridae and Phascolarctidae. Gen Comp Endocrinol. 1987 Sep;67(3):399-408. PubMed PMID: 3666414.
5: Acher R. The nonmammalian-mammalian transition through neurohypophysial peptides. Peptides. 1985;6 Suppl 3:309-14. PubMed PMID: 3831965.
6: Chauvet J, Hurpet D, Michel G, Chauvet MT, Acher R. Two multigene families for marsupial neurohypophysial hormones? Identification of oxytocin, mesotocin, lysipressin and arginine vasopressin in the North American opossum (Didelphis virginiana). Biochem Biophys Res Commun. 1984 Aug 30;123(1):306-11. PubMed PMID: 6477584.
7: Chauvet MT, Colne T, Hurpet D, Chauvet J, Acher R. A multigene family for the vasopressin-like hormones? Identification of mesotocin, lysipressin and phenypressin in Australian macropods. Biochem Biophys Res Commun. 1983 Oct 14;116(1):258-63. PubMed PMID: 6639661.