m-PEG1-NHS ester

• CAT Number: I017231
• CAS Number: 1027371-75-0
• Molecular Formula: C8H11NO5
• Molecular Weight: 201.18
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 3-methoxypropanoate
• InChI: InChI=1S/C8H11NO5/c1-13-5-4-8(12)14-9-6(10)2-3-7(9)11/h2-5H2,1H3
• InChIKey: GDPPBYZKFKEXML-UHFFFAOYSA-N
• SMILES: COCCC(=O)ON1C(=O)CCC1=O

m-PEG1-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Reference

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.
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