m-PEG11-acid

• CAT Number: I016796
• CAS Number: 2280998-74-3
• Molecular Formula: C₂₄H₄₈O₁₃
• Molecular Weight: 544.63
• Purity: ≥95%
• Target: PROTAC
• IUPAC Name: 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C24H48O13/c1-27-4-5-29-8-9-31-12-13-33-16-17-35-20-21-37-23-22-36-19-18-34-15-14-32-11-10-30-7-6-28-3-2-24(25)26/h2-23H2,1H3,(H,25,26)
• InChIKey: XTRVAOVFCQZNBJ-UHFFFAOYSA-N
• SMILES: COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

m-PEG11-acid（Cat No.:I016796） is a linker molecule that contains 11 polyethylene glycol (PEG) units and is used to synthesize antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). As an ADC linker, it is non-cleavable and is used to attach drugs to the targeting antibody. As a PROTAC linker, it belongs to the PEG class and is used to connect the ligand for the target protein with a ligand for an E3 ubiquitin ligase, leading to targeted protein degradation. The PEG units in m-PEG11-acid provide water solubility and improve the pharmacokinetic properties of the resulting ADCs and PROTACs.

Reference

[1]. Wilfried Braje et al. Macrocyclic mcl-1 inhibitors and methods of use. WO2019035927A1.[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.