For research use only. Not for therapeutic Use.
m-PEG11-Amino is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). It consists of an 11-unit polyethylene glycol (PEG) spacer attached to an amino group, allowing for conjugation to the antibody or targeting moiety. The cleavable nature of the linker enables the release of the drug payload from the ADC within the target cell. Additionally, m-PEG11-Amino is classified as a PEG-based PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation in drug discovery and therapeutics.
| Catalog Number | I014478 |
| CAS Number | 854601-60-8 |
| Synonyms | m-PEG11-amine;2,5,8,11,14,17,20,23,26,29,32-undecaoxatetratriacontan-34-amine |
| Molecular Formula | C23H49NO11 |
| Purity | ≥95% |
| Target | PROTAC |
| Solubility | Soluble in DMSO |
| IUPAC Name | 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine |
| InChI | InChI=1S/C23H49NO11/c1-25-4-5-27-8-9-29-12-13-31-16-17-33-20-21-35-23-22-34-19-18-32-15-14-30-11-10-28-7-6-26-3-2-24/h2-24H2,1H3 |
| InChIKey | SWAJVHMMXALQKJ-UHFFFAOYSA-N |
| SMILES | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN |
| Reference | </br>1: Pignatello R, Impallomeni G, Pistarà V, Cupri S, Graziano AC, Cardile V, Ballistreri A. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG(5000) polymers. Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. doi: 10.1016/j.msec.2014.10.054. Epub 2014 Oct 23. PubMed PMID: 25492012.</br>2: Rubio-Garcia J, Coppel Y, Lecante P, Mingotaud C, Chaudret B, Gauffre F, Kahn ML. One-step synthesis of metallic and metal oxide nanoparticles using amino-PEG oligomers as multi-purpose ligands: size and shape control, and quasi-universal solvent dispersibility. Chem Commun (Camb). 2011 Jan 21;47(3):988-90. doi: 10.1039/c0cc02615h. Epub 2010 Nov 26. PubMed PMID: 21113535.</br>3: Kitagawa F, Kubota K, Sueyoshi K, Otsuka K. One-step preparation of amino-PEG modified poly(methyl methacrylate) microchips for electrophoretic separation of biomolecules. J Pharm Biomed Anal. 2010 Dec 15;53(5):1272-7. doi: 10.1016/j.jpba.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20678876.</br>4: Yoshimoto K, Hoshino Y, Ishii T, Nagasaki Y. Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using alpha-sulfanyl-omega-amino-PEG. Chem Commun (Camb). 2008 Nov 14;(42):5369-71. doi: 10.1039/b811818c. Epub 2008 Sep 16. PubMed PMID: 18985213.</br></br> |
