For research use only. Not for therapeutic Use.
m-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
| Catalog Number | I016965 |
| CAS Number | 215181-61-6 |
| Synonyms | 1-azido-2-(2-methoxyethoxy)ethane |
| Molecular Formula | C5H11N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C5H11N3O2/c1-9-4-5-10-3-2-7-8-6/h2-5H2,1H3 |
| InChIKey | OXDZFVNIVMSPEG-UHFFFAOYSA-N |
| SMILES | COCCOCCN=[N+]=[N-] |
| Reference | [1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67. |
