For research use only. Not for therapeutic Use.
m-PEG2-O-Ph-3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044720 |
| CAS Number | 126415-02-9 |
| Synonyms | 3-[2-(2-methoxyethoxy)ethoxy]aniline |
| Molecular Formula | C11H17NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H17NO3/c1-13-5-6-14-7-8-15-11-4-2-3-10(12)9-11/h2-4,9H,5-8,12H2,1H3 |
| InChIKey | DEOFYPCJGRLJKB-UHFFFAOYSA-N |
| SMILES | COCCOCCOC1=CC=CC(=C1)N |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
