m-PEG2-O-Ph-NH2

• CAT Number: I044721
• CAS Number: 65673-48-5
• Molecular Formula: C11H17NO3
• Molecular Weight: 211.26
• Purity: ≥95%
• Synonyms: 4-[2-(2-methoxyethoxy)ethoxy]aniline
• InChI: InChI=1S/C11H17NO3/c1-13-6-7-14-8-9-15-11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3
• InChIKey: IWXQVPLYQQTJTR-UHFFFAOYSA-N
• SMILES: COCCOCCOC1=CC=C(C=C1)N

m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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