m-PEG3-aldehyde

For research use only. Not for therapeutic Use.

  • CAT Number: I017152
  • CAS Number: 356066-46-1
  • Molecular Formula: C8H16O4
  • Molecular Weight: 176.21
  • Purity: ≥95%
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m-PEG3-aldehyde is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
The binding affinities of anti-mPEGs depend more on the backbone lengths of the polymers and the hydrophobicities of their end-groups than on their resemblance to the methoxy terminus of the immunogenic polymer[1].
Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The hydrophilic PEG spacer increases solubility in aqueous media.


Catalog Number I017152
CAS Number 356066-46-1
Synonyms

3-[2-(2-methoxyethoxy)ethoxy]propanal

Molecular Formula C8H16O4
Purity ≥95%
InChI InChI=1S/C8H16O4/c1-10-5-6-12-8-7-11-4-2-3-9/h3H,2,4-8H2,1H3
InChIKey OBRBOVOZENLKGQ-UHFFFAOYSA-N
SMILES COCCOCCOCCC=O
Reference

[1]. Saifer MG, et al.Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins.Mol Immunol. 2014 Feb;57(2):236-46.
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