m-PEG3-SH

• CAT Number: I016299
• CAS Number: 31521-83-2
• Molecular Formula: C7H16O3S
• Molecular Weight: 180.27
• Purity: ≥95%
• Synonyms: 2-[2-(2-methoxyethoxy)ethoxy]ethanethiol
• InChI: InChI=1S/C7H16O3S/c1-8-2-3-9-4-5-10-6-7-11/h11H,2-7H2,1H3
• InChIKey: DMFFSDWRRLCKKN-UHFFFAOYSA-N
• SMILES: COCCOCCOCCS

m-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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