m-PEG3-succinimidyl carbonate

• CAT Number: I016645
• CAS Number: 477775-77-2
• Molecular Formula: C₁₂H₁₉NO₈
• Molecular Weight: 305.28
• Purity: ≥95%
• Target: PROTAC Linkers

m-PEG3-succinimidyl carbonate (CAT: I016645) serves as a PEG-based PROTAC linker, playing a vital role in the synthesis of Proteolysis-Targeting Chimeras (PROTACs). These innovative molecules are designed to selectively degrade disease-associated proteins within cells. As a linker, m-PEG3-succinimidyl carbonate facilitates the conjugation of the ligand that binds to the target protein with the ligand that recruits an E3 ubiquitin ligase, triggering protein degradation.

Reference

[1]. Miller MA, et al. Amphiphilic conjugates of human brain natriuretic peptide designed for oral delivery: in vitro activity screening. Bioconjug Chem. 2006 Mar-Apr;17(2):267-74.