For research use only. Not for therapeutic Use.
m-PEG4-azide (13-Azido-2,5,8,11-tetraoxatridecane) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. m-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I015787 |
| CAS Number | 606130-90-9 |
| Synonyms | 1-azido-2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethane |
| Molecular Formula | C9H19N3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C9H19N3O4/c1-13-4-5-15-8-9-16-7-6-14-3-2-11-12-10/h2-9H2,1H3 |
| InChIKey | FFOZZVDSANUDAE-UHFFFAOYSA-N |
| SMILES | COCCOCCOCCOCCN=[N+]=[N-] |
| Reference | [1]. Belen Begines, et al. Synthesis of Reduction Sensitive Comb-Like Polyurethanes Using Click Chemistry. Journal of Polymer Science Part A: Polymer Chemistry, 2016, 54(24), 3888-3900. |
