For research use only. Not for therapeutic Use.
m-PEG4-C6-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016510 |
| CAS Number | 2028281-89-0 |
| Synonyms | 1-diethoxyphosphoryl-8-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]octane |
| Molecular Formula | C19H41O7P |
| Purity | ≥95% |
| InChI | InChI=1S/C19H41O7P/c1-4-25-27(20,26-5-2)19-11-9-7-6-8-10-12-22-15-16-24-18-17-23-14-13-21-3/h4-19H2,1-3H3 |
| InChIKey | CNDORYGJXMHDBX-UHFFFAOYSA-N |
| SMILES | CCOP(=O)(CCCCCCCCOCCOCCOCCOC)OCC |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
