For research use only. Not for therapeutic Use.
m-PEG4-CH2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I015952 |
| CAS Number | 874208-84-1 |
| Synonyms | 4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]butanoic acid |
| Molecular Formula | C11H22O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H22O6/c1-14-5-6-16-9-10-17-8-7-15-4-2-3-11(12)13/h2-10H2,1H3,(H,12,13) |
| InChIKey | HKQFGVZYAYHZJS-UHFFFAOYSA-N |
| SMILES | COCCOCCOCCOCCCC(=O)O |
| Reference | [1]. Zuluaga MF, et al. Enhanced prostate cancer targeting by modified protease sensitive photosensitizer prodrugs. Mol Pharm. 2012 Jun 4;9(6):1570-9. |
