m-PEG4-CH2-acid

• CAT Number: I015952
• CAS Number: 874208-84-1
• Molecular Formula: C11H22O6
• Molecular Weight: 250.29
• Purity: ≥95%
• Synonyms: 4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]butanoic acid
• InChI: InChI=1S/C11H22O6/c1-14-5-6-16-9-10-17-8-7-15-4-2-3-11(12)13/h2-10H2,1H3,(H,12,13)
• InChIKey: HKQFGVZYAYHZJS-UHFFFAOYSA-N
• SMILES: COCCOCCOCCOCCCC(=O)O

m-PEG4-CH2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. Zuluaga MF, et al. Enhanced prostate cancer targeting by modified protease sensitive photosensitizer prodrugs. Mol Pharm. 2012 Jun 4;9(6):1570-9.
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