For research use only. Not for therapeutic Use.
m-PEG4-CH2-methyl ester is a PEG- and Alkyl/ester-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016447 |
| CAS Number | 1920109-55-2 |
| Synonyms | methyl 4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]butanoate |
| Molecular Formula | C12H24O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H24O6/c1-14-6-7-17-10-11-18-9-8-16-5-3-4-12(13)15-2/h3-11H2,1-2H3 |
| InChIKey | XIAKKRXIAOWIKK-UHFFFAOYSA-N |
| SMILES | COCCOCCOCCOCCCC(=O)OC |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
