m-PEG4-NH-DBCO

• CAT Number: I016043
• CAS Number: 2228857-36-9
• Molecular Formula: C₂₈H₃₄N₂O₆
• Molecular Weight: 494.58
• Purity: ≥95%
• Target: PROTAC Linkers

m-PEG4-NH-DBCO(CAT: I016043) is a polyethylene glycol (PEG) derivative containing a DBCO (dibenzocyclooctyne) functional group and an amino group. The PEG spacer has a length of four ethylene glycol units. The DBCO group is commonly used in bioconjugation chemistry for the specific and efficient labeling of molecules with azide-containing compounds through a copper-free click reaction known as strain-promoted azide-alkyne cycloaddition (SPAAC). The amino group of m-PEG4-NH-DBCO can react with various activated esters or NHS esters to introduce functional groups or linkers onto biomolecules for further conjugation or modification.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562