m-PEG4-NHS ester

• CAT Number: I017150
• CAS Number: 622405-78-1
• Molecular Formula: C₁₄H₂₃NO₈
• Molecular Weight: 333.33
• Purity: ≥95%
• Target: PROTAC Linkers

m-PEG4-NHS ester(CAT: I017150) stands as a pivotal component within the realm of PROTAC-based drug design. This PEG-based linker is equipped with a N-hydroxysuccinimide (NHS) ester functionality, facilitating its conjugation to target ligands. By serving as a bridge between the ligand targeting the protein of interest and the ligand for E3 ubiquitin ligase, m-PEG4-NHS ester enables the assembly of PROTACs.

Reference

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.