For research use only. Not for therapeutic Use.
m-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016512 |
| CAS Number | 1872433-73-2 |
| Synonyms | 1-[2-[2-(2-diethoxyphosphorylethoxy)ethoxy]ethoxy]-2-methoxyethane |
| Molecular Formula | C13H29O7P |
| Purity | ≥95% |
| InChI | InChI=1S/C13H29O7P/c1-4-19-21(14,20-5-2)13-12-18-11-10-17-9-8-16-7-6-15-3/h4-13H2,1-3H3 |
| InChIKey | IJIFYTYZSWFMQQ-UHFFFAOYSA-N |
| SMILES | CCOP(=O)(CCOCCOCCOCCOC)OCC |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
