For research use only. Not for therapeutic Use.
m-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Catalog Number | I016085 |
CAS Number | 787524-78-1 |
Synonyms | 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanesulfonic acid |
Molecular Formula | C9H20O7S |
Purity | ≥95% |
InChI | InChI=1S/C9H20O7S/c1-13-2-3-14-4-5-15-6-7-16-8-9-17(10,11)12/h2-9H2,1H3,(H,10,11,12) |
InChIKey | JOLNKYKZGYOWSY-UHFFFAOYSA-N |
SMILES | COCCOCCOCCOCCS(=O)(=O)O |
Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |