m-PEG5-acid

For research use only. Not for therapeutic Use.

  • CAT Number: I016717
  • CAS Number: 81836-43-3
  • Molecular Formula: C₁₂H₂₄O₇
  • Molecular Weight: 280.31
  • Purity: ≥95%
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m-PEG5-acid(Cat No.:I016717) is a polyethylene glycol (PEG)-based linker molecule commonly used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It serves as a crucial component that connects the target protein ligand and the E3 ligase ligand in a PROTAC molecule. m-PEG5-acid provides flexibility and hydrophilicity to the linker region, allowing for optimal binding and interaction between the target protein and the E3 ligase. This linker enables the formation of stable and effective PROTAC molecules, which can selectively degrade target proteins and hold promise in the field of targeted protein degradation for various therapeutic applications.


Catalog Number I016717
CAS Number 81836-43-3
Molecular Formula C₁₂H₂₄O₇
Purity ≥95%
Target PROTAC Linkers
IUPAC Name 3-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]propanoic acid
InChI InChI=1S/C12H24O7/c1-15-4-5-17-8-9-19-11-10-18-7-6-16-3-2-12(13)14/h2-11H2,1H3,(H,13,14)
InChIKey KTTNUZHOERZAMX-UHFFFAOYSA-N
SMILES COCCOCCOCCOCCOCCC(=O)O
Reference

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

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