For research use only. Not for therapeutic Use.
M-PEG5-Br is a PEG-based linker that is commonly used in the synthesis of proteolysis-targeting chimeras (PROTACs), a type of small molecule that targets specific proteins for degradation via the ubiquitin-proteasome system. The PEG (polyethylene glycol) component of the linker provides water solubility and flexibility, while the bromine atom facilitates attachment to the target protein or ligand. M-PEG5-Br has a molecular weight of approximately 453 g/mol and consists of a five-unit PEG chain with a methoxy group at one end and a bromine atom at the other end.
| Catalog Number | I016462 |
| CAS Number | 854601-80-2 |
| Molecular Formula | C₁₁H₂₃BrO₅ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Storage | 2-8°C |
| IUPAC Name | 1-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]-2-methoxyethane |
| InChI | InChI=1S/C11H23BrO5/c1-13-4-5-15-8-9-17-11-10-16-7-6-14-3-2-12/h2-11H2,1H3 |
| InChIKey | BYGAERKSEUTLAH-UHFFFAOYSA-N |
| SMILES | COCCOCCOCCOCCOCCBr |
| Reference | [1]. Jennifer Riggs-Sauthier, et al. Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates. US20120094998A1. |
