m-PEG5-NHS ester

• CAT Number: I016905
• CAS Number: 874208-94-3
• Molecular Formula: C16H27NO9
• Molecular Weight: 377.39
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C16H27NO9/c1-21-6-7-23-10-11-25-13-12-24-9-8-22-5-4-16(20)26-17-14(18)2-3-15(17)19/h2-13H2,1H3
• InChIKey: FMMFVGSOBIANGY-UHFFFAOYSA-N
• SMILES: COCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

m-PEG5-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Reference

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.
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