m-PEG6-2-methylacrylate

• CAT Number: I016972
• CAS Number: 90784-86-4
• Molecular Formula: C17H32O8
• Molecular Weight: 364.43
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate
• InChI: InChI=1S/C17H32O8/c1-16(2)17(18)25-15-14-24-13-12-23-11-10-22-9-8-21-7-6-20-5-4-19-3/h1,4-15H2,2-3H3
• InChIKey: FVSGBTSAXJGUNZ-UHFFFAOYSA-N
• SMILES: CC(=C)C(=O)OCCOCCOCCOCCOCCOCCOC

m-PEG6-2-methylacrylate is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. Zhu C, et al. Reversibly shielded DNA polyplexes based on bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA triblock copolymers mediate markedly enhanced nonviral gene transfection. Biomacromolecules. 2012 Mar 12;13(3):769-78.
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