For research use only. Not for therapeutic Use.
m-PEG6-CH2CH2CHO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG6-CH2CH2CHO is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
| Catalog Number | I016724 |
| CAS Number | 1058691-77-2 |
| Synonyms | 3-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanal |
| Molecular Formula | C16H32O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H32O8/c1-18-5-6-20-9-10-22-13-14-24-16-15-23-12-11-21-8-7-19-4-2-3-17/h3H,2,4-16H2,1H3 |
| InChIKey | OFRPYQRIPDCCAA-UHFFFAOYSA-N |
| SMILES | COCCOCCOCCOCCOCCOCCOCCC=O |
| Reference | [1]. Erwin R. Boghaert, et al. Anti-egfr antibody drug conjugates. WO2017214282A1. |
