For research use only. Not for therapeutic Use.
m-PEG6-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016495 |
| CAS Number | 441771-60-4 |
| Synonyms | 2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol |
| Molecular Formula | C13H28O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C13H28O6S/c1-14-2-3-15-4-5-16-6-7-17-8-9-18-10-11-19-12-13-20/h20H,2-13H2,1H3 |
| InChIKey | FCNSUDTWFXNQBG-UHFFFAOYSA-N |
| SMILES | COCCOCCOCCOCCOCCOCCS |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
