m-PEG8-CH2COOH

• CAT Number: M131866
• CAS Number: 102013-72-9
• Molecular Formula: C19H38O11
• Molecular Weight: 442.50
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
• InChI: InChI=1S/C19H38O11/c1-22-2-3-23-4-5-24-6-7-25-8-9-26-10-11-27-12-13-28-14-15-29-16-17-30-18-19(20)21/h2-18H2,1H3,(H,20,21)
• InChIKey: AOKQPSPNBHUGLR-UHFFFAOYSA-N
• SMILES: COCCOCCOCCOCCOCCOCCOCCOCCOCC(=O)O

m-PEG8-CH2COOH is a PEG–based PROTAC linker can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Reference

[1]. Alexander Chucholowski, et al. Cyclodextrin conjugates. WO2010017328A2.