For research use only. Not for therapeutic Use.
m-PEG8-NHS ester(CAT: I016727) is a non-cleavable eight-unit polyethylene glycol (PEG) linker functionalized with an N-hydroxysuccinimide (NHS) ester group. This linker is widely used in the synthesis of antibody-drug conjugates (ADCs), a class of therapeutic agents that combines the targeting specificity of monoclonal antibodies with the cytotoxic potency of small-molecule drugs. In ADCs, the m-PEG8-NHS ester is attached to the antibody, and the NHS group facilitates the conjugation of the cytotoxic drug to the linker, which is ultimately connected to the antibody.
| Catalog Number | I016727 |
| CAS Number | 756525-90-3 |
| Molecular Formula | C₂₂H₃₉NO₁₂ |
| Purity | ≥95% |
| Reference | [1]. By Boehnke, et al. Preparation of antibody drug conjugates with NAMPT inhibitors for use in treatment of cancer. Patent WO2019149637A1. |
