For research use only. Not for therapeutic Use.
M-TriDAP(CAT: I040745) (Muramyl-Tri-DAP, N-acetylmuramyl-L-Ala-D-Glu-meso-DAP) is a synthetic derivative of bacterial peptidoglycan and a potent agonist of the intracellular pattern recognition receptor NOD1. It mimics natural components of Gram-negative bacterial cell walls, making it a valuable tool in immunology research. M-TriDAP effectively activates NOD1-mediated signaling pathways, triggering NF-κB activation and pro-inflammatory cytokine production. It is widely used to study innate immune responses, host-pathogen interactions, and inflammatory signaling cascades. Highly stable and bioactive, M-TriDAP is ideal for in vitro and in vivo studies focused on innate immunity, infectious disease models, and NOD-like receptor biology.
| CAS Number | 60230-21-9 |
| Synonyms | 2-[[(4R)-4-[[(2S)-2-[[(2R)-2-[(2R,3R,4R,5R)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxypropanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-6-aminoheptanedioic acid |
| Molecular Formula | C26H43N5O15 |
| Purity | ≥95% |
| IUPAC Name | 2-[[(4R)-4-[[(2S)-2-[[(2R)-2-[(2R,3R,4R,5R)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxypropanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-6-aminoheptanedioic acid |
| InChI | InChI=1S/C26H43N5O15/c1-11(28-23(39)12(2)46-21(20(37)18(35)10-33)17(9-32)29-13(3)34)22(38)31-16(26(44)45)7-8-19(36)30-15(25(42)43)6-4-5-14(27)24(40)41/h9,11-12,14-18,20-21,33,35,37H,4-8,10,27H2,1-3H3,(H,28,39)(H,29,34)(H,30,36)(H,31,38)(H,40,41)(H,42,43)(H,44,45)/t11-,12+,14?,15?,16+,17-,18+,20+,21+/m0/s1 |
| InChIKey | VMWCJJZYTQZDJQ-IWAOCOHZSA-N |
| SMILES | C[C@@H](C(=O)N[C@H](CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)NC(=O)[C@@H](C)O[C@H]([C@H](C=O)NC(=O)C)[C@@H]([C@@H](CO)O)O |
