For research use only. Not for therapeutic Use.
M1001(CAT: I019507) is a weak agonist of the hypoxia-inducible factor 2-alpha (HIF-2α) and directly binds to the PAS-B domain of HIF-2α, with a dissociation constant (Kd) of 667 nM. Furthermore, M1001 enhances the stability of the HIF-2α-Arnt (aryl hydrocarbon receptor nuclear translocator) complex. This suggests that M1001 may have potential implications in modulating HIF-2α signaling and its associated pathways.
| Catalog Number | I019507 |
| CAS Number | 874590-32-6 |
| Molecular Formula | C₁₇H₁₇N₃O₂S |
| Purity | ≥95% |
| Target | HIF/HIF Prolyl-Hydroxylase |
| Reference | [1]. Wu D, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Feb 25. |
