M1069 free base

• CAT Number: I040180
• CAS Number: 2459881-03-7
• Molecular Formula: C21H26N4O4S
• Molecular Weight: 430.52
• Purity: ≥95%
• Synonyms: (5S)-N-[7-(3,6-dihydro-2H-pyran-4-yl)-4-methoxy-[1,3]thiazolo[4,5-c]pyridin-2-yl]-7-oxa-2-azaspiro[4.5]decane-2-carboxamide
• InChI: InChI=1S/C21H26N4O4S/c1-27-18-16-17(15(11-22-18)14-3-9-28-10-4-14)30-19(23-16)24-20(26)25-7-6-21(12-25)5-2-8-29-13-21/h3,11H,2,4-10,12-13H2,1H3,(H,23,24,26)/t21-/m0/s1
• InChIKey: CSSAKLQGJYJMNW-NRFANRHFSA-N
• SMILES: COC1=NC=C(C2=C1N=C(S2)NC(=O)N3CCC4(C3)CCCOC4)C5=CCOCC5

M1069 free base (Cat No.: I040180) is a chemical compound studied for its potential therapeutic applications, particularly in the treatment of autoimmune diseases and cancer. It functions as a selective modulator of specific protein interactions, impacting pathways related to inflammation and immune response. M1069 free base is often explored for its ability to inhibit the activity of key enzymes or receptors involved in disease progression. Ongoing research aims to evaluate its efficacy, safety, and mechanisms of action in various preclinical models and clinical settings.

Reference

[1]. Rinat Zaynagetdinov, et al. Abstract 3499: M1069 as dual A2A/A2B adenosine receptor antagonist counteracts immune-suppressive mechanisms of adenosine and reduces tumor growth in vivo. Cancer Res (2022) 82 (12_Supplement):3499.

[2]. Lillian L Siu, et al. Abstract CT240: A first-in-human study of the dual A2A/A2B adenosine receptor antagonist M1069 in patients with advanced solid tumors. Cancer Res (2022) 82 (12_Supplement):CT240.

[3]. Tanzer Eva-Maria, et al. Preparation of thiazolopyridine derivatives as adenosine receptor antagonists: World Intellectual Property Organization, WO2020152132[P]. 2020-07-30.