M2I-1

• CAT Number: I003100
• CAS Number: 312271-03-7
• Molecular Formula: C19H24N4O4S
• Molecular Weight: 404.48
• Purity: ≥95%
• Synonyms: 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
• InChI: InChI=1S/C19H24N4O4S/c1-11(2)9-22(10-12(3)4)15-6-5-13(8-16(15)23(26)27)7-14-17(24)20-19(28)21-18(14)25/h5-8,11-12H,9-10H2,1-4H3,(H2,20,21,24,25,28)
• InChIKey: BWEKPQUKWLNUKX-UHFFFAOYSA-N
• SMILES: CC(C)CN(CC(C)C)C1=C(C=C(C=C1)C=C2C(=O)NC(=S)NC2=O)[N+](=O)[O-]

M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC)[1].
M2I-1 may not be sufficiently potent to fully inhibit SAC function in cells[1].
M2I-1 weakens the SAC response, indicating that the compound might be active in cells.[1].

Reference

[1]. Johanna Kastl et al. Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint. ACS Chem. Biol., 2015, 10 (7), pp 1661-1666.
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