M344

• CAT Number: I002855
• CAS Number: 251456-60-7
• Molecular Formula: C₁₆H₂₅N₃O₃
• Molecular Weight: 307.39
• Purity: ≥95%
• Synonyms: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
• Target: Epigenetics
• Solubility: DMSO 62mg/mL; Water <1 mg/mL; Ethanol 4 mg/mL
• Storage: 3 years -20C powder
• IC50: 0.34uM(in K562 cell)[1]
• InChI: InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
• InChIKey: MXWDSZWTBOCWBK-UHFFFAOYSA-N
• SMILES: CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO

M344(Cat No.:I002855) is a histone deacetylase (HDAC) inhibitor known for its potential anticancer activity. By inhibiting HDACs, M344 promotes histone acetylation, leading to altered gene expression, cell cycle arrest, and apoptosis in cancer cells. It has been shown to enhance the effects of other chemotherapeutic agents and is used in research to study epigenetic regulation and tumor suppression mechanisms. M344 is especially valuable in exploring the role of chromatin remodeling in cancer progression and may serve as a lead compound in epigenetic therapy development.

Reference

[1]. Wittich S, Scherf H, Xie C, Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and humanerythroleukemia cell lines. Anticancer Drugs. 2005 Jul;16(6):635-43.
[2]. Yeung A, Bhargava RK, Ahn R, HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation. Biomed Pharmacother. 2012 Apr;66(3):232-6.
[3]. Weberpals JI, O/’Brien AM, Niknejad N, The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells. Cancer Cell Int. 2011 Aug 19;11(1):29.
[4]. Furchert SE, Lanvers-Kaminsky C, Juürgens H, Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. Int J Cancer. 2007 Apr 15;120(8):1787-94.
[5]. Riessland M, Brichta L, Hahnen E, The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells. Hum Genet. 2006 Aug;120(1):101-10.