M344

• CAT Number: I002855
• CAS Number: 251456-60-7
• Molecular Formula: C₁₆H₂₅N₃O₃
• Molecular Weight: 307.39
• Purity: ≥95%
• Synonyms: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
• Target: HDAC
• Solubility: DMSO 62mg/mL; Water <1 mg/mL; Ethanol 4 mg/mL
• Storage: 3 years -20C powder
• IC50: 0.34uM(in K562 cell)[1]
• InChI: InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
• InChIKey: MXWDSZWTBOCWBK-UHFFFAOYSA-N
• SMILES: CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO

M344(Cat No.:I002855) also known as 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide.M344 (D 237) is a histone deacetylase inhibitor, IC50 is 100 nM, and the main target is HDAC. It is a small molecule inhibitor with good activity, widely used in anti-tumor research.

Reference

[1]. Wittich S, Scherf H, Xie C, Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and humanerythroleukemia cell lines. Anticancer Drugs. 2005 Jul;16(6):635-43.
[2]. Yeung A, Bhargava RK, Ahn R, HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation. Biomed Pharmacother. 2012 Apr;66(3):232-6.
[3]. Weberpals JI, O/’Brien AM, Niknejad N, The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells. Cancer Cell Int. 2011 Aug 19;11(1):29.
[4]. Furchert SE, Lanvers-Kaminsky C, Juürgens H, Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. Int J Cancer. 2007 Apr 15;120(8):1787-94.
[5]. Riessland M, Brichta L, Hahnen E, The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells. Hum Genet. 2006 Aug;120(1):101-10.