M4 mAChR agonist-1

• CAT Number: I043538
• CAS Number: 785705-53-5
• Molecular Formula: C14H18N4OS
• Molecular Weight: 290.38
• Purity: ≥95%
• Synonyms: 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
• InChI: InChI=1S/C14H18N4OS/c1-8-9(2)20-14-11(8)13(16-7-17-14)18-5-3-10(4-6-18)12(15)19/h7,10H,3-6H2,1-2H3,(H2,15,19)
• InChIKey: KOMCJGHOPXNACW-UHFFFAOYSA-N
• SMILES: CC1=C(SC2=NC=NC(=C12)N3CCC(CC3)C(=O)N)C

M4 mAChR agonist-1 (compound 10a) is a potent M4 mAChR agonist with an EC50 >10 μM for human M4[1].

Reference

[1]. Wood MR, et al. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2016;26(13):3029-3033.
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