For research use only. Not for therapeutic Use.
M410 is a vascular disrupting agent, which showed potent cytotoxic activity toward proliferating tumor cells and exhibited a similar cytotoxicity against multi-drug resistant (MDR) tumor cells. M410 inhibited bovine brain tubulin polymerization in a way similar to that of colchicine. In proliferating human umbilical vein endothelial cells (HUVECs), 20 nM of M410 induced cellular tubulin depolymerization within 4 h, which led to M phase arrest. M410 is a potent microtubule inhibitor that is cytotoxic, angiogenesis inhibiting and vascular targeting.
| Catalog Number | I007692 |
| Synonyms | M410; M-410; M 410.;sodium (Z)-5-(3,5-dimethoxystyryl)-2-methoxyphenyl phosphate |
| Molecular Formula | C17H17Na2O7P |
| Purity | ≥95% |
| Solubility | Soluble in water, Soluble in DMSO. |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| Reference | </br>1:M410, a combretastatin A4 analogue, disrupts microtubules and inhibits HIF-1α in human breast cancer cells. Yang H, Xia Q, Zou Y, Wang K, Jiang W, Cai Y.Oncol Rep. 2015 Jul;34(1):334-40. doi: 10.3892/or.2015.3975. Epub 2015 May 12. PMID: 25976207 </br>2:In vivo assessment of the vascular disrupting effect of M410 by DCE-MRI biomarker in a rabbit model of liver tumor. Yang RM, Zou Y, Huang DP, Lai SS, Xu XD, Wei XH, Chang HZ, Huang TK, Wang L, Tang WJ, Jiang XQ.Oncol Rep. 2014 Aug;32(2):709-15. doi: 10.3892/or.2014.3230. Epub 2014 Jun 4. PMID: 24898785 </br>3:Anti-tumor activity and mechanisms of a novel vascular disrupting agent, (Z)-3,4/’,5-trimethoxylstilbene-3/’-O-phosphate disodium (M410). Cai YC, Zou Y, Ye YL, Sun HY, Su QG, Wang ZX, Zeng ZL, Xian LJ.Invest New Drugs. 2011 Apr;29(2):300-11. doi: 10.1007/s10637-009-9366-x. Epub 2009 Dec 11. PMID: 20012336 |
