For research use only. Not for therapeutic Use.
M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC50s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer[1].
M4K2234 (0-5 μM) shows inhibitory effects against WT and DIPG-linked mutant forms of ALK2 with IC50s of 5, 3, 6 and 6 nM for WT, G328V, R206H and R258G, respectively[1].
1.19
Pharmacokinetic Properties of M4K2234 in Mice [1].
MicePO 3 mg/kg
Cmax(ng/mL)
1650
AUCinf(ng·h/mL)
4630
t1/2(h)
2.61
| Catalog Number | I042642 |
| CAS Number | 2421141-51-5 |
| Synonyms | 2-fluoro-6-methoxy-4-[4-methyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pyridin-3-yl]benzamide |
| Molecular Formula | C27H31FN4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H31FN4O2/c1-17(2)31-9-11-32(12-10-31)21-7-5-19(6-8-21)22-15-30-16-23(18(22)3)20-13-24(28)26(27(29)33)25(14-20)34-4/h5-8,13-17H,9-12H2,1-4H3,(H2,29,33) |
| InChIKey | RIWTUJFFSTVYPW-UHFFFAOYSA-N |
| SMILES | CC1=C(C=NC=C1C2=CC=C(C=C2)N3CCN(CC3)C(C)C)C4=CC(=C(C(=C4)F)C(=O)N)OC |
| Reference | [1]. Ensan D, et al. Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 May 14;63(9):4978-4996. |
