For research use only. Not for therapeutic Use.
M5N36 is a potent and selective Cdc25C inhibitor with IC50 values of 0.15, 0.19, 0.06 µM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2[1].
M5N36 (5, 10 µM; 24 h) increases the expression of p-CDK1 and p-CDK2 in MDA-MB-231 cells[1].
| Catalog Number | I042019 |
| CAS Number | 2832887-40-6 |
| Synonyms | 6-chloro-7-[1-[1-[4-(hydroxymethyl)phenyl]triazol-4-yl]ethylamino]quinoline-5,8-dione |
| Molecular Formula | C20H16ClN5O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H16ClN5O3/c1-11(15-9-26(25-24-15)13-6-4-12(10-27)5-7-13)23-18-16(21)19(28)14-3-2-8-22-17(14)20(18)29/h2-9,11,23,27H,10H2,1H3 |
| InChIKey | XSEYUBHGRYYOGZ-UHFFFAOYSA-N |
| SMILES | CC(C1=CN(N=N1)C2=CC=C(C=C2)CO)NC3=C(C(=O)C4=C(C3=O)N=CC=C4)Cl |
| Reference | [1]. Tao Y, et al. Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries. Bioorg Chem. 2021 Oct;115:105254. |
