MAC glucuronide linker-2

• CAT Number: I017659
• CAS Number: 229977-57-5
• Molecular Formula: C₂₀H₂₅NO₁₁
• Molecular Weight: 455.41
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: methyl (2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[2-amino-4-(hydroxymethyl)phenoxy]oxane-2-carboxylate
• InChI: InChI=1S/C20H25NO11/c1-9(23)28-15-16(29-10(2)24)18(30-11(3)25)20(32-17(15)19(26)27-4)31-14-6-5-12(8-22)7-13(14)21/h5-7,15-18,20,22H,8,21H2,1-4H3/t15-,16-,17-,18+,20+/m0/s1
• InChIKey: ZAZPQJAJSIUIEY-KVIJGQROSA-N
• SMILES: CC(=O)OC1C(C(OC(C1OC(=O)C)OC2=C(C=C(C=C2)CO)N)C(=O)OC)OC(=O)C

MAC glucuronide linker-2（Cat No.:I017659）is a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs). This linker incorporates a glucuronide moiety that enables site-specific attachment of the linker to the antibody. The linker is designed to be stable during circulation in the bloodstream but undergoes cleavage in the targeted cancer cells, releasing the attached cytotoxic drug. This cleavage mechanism allows for precise drug delivery and enhances the therapeutic efficacy of ADCs by selectively delivering the drug payload to the tumor cells, minimizing off-target effects, and maximizing the anticancer activity.

Reference

[1]. Robert A, et al. Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues. WO2019136298A1.