MAC glucuronide phenol-linked SN-38

• CAT Number: I018025
• CAS Number: 2246380-69-6
• Molecular Formula: C₅₀H₅₄N₆O₂₀S
• Molecular Weight: 1091.06
• Purity: ≥95%
• Target: Drug-Linker Conjugates for ADC
• InChI: InChI=1S/C50H52N6O20S/c1-5-27-28-18-26(8-9-32(28)52-40-29(27)20-56-34(40)19-31-30(45(56)64)23-72-48(67)50(31,69)6-2)74-24-54(15-16-77(4,70)71)49(68)73-22-25-7-10-35(75-47-43(63)41(61)42(62)44(76-47)46(65)66)33(17-25)51-36(57)21-53(3)37(58)13-14-55-38(59)11-12-39(55)60/h7-12,17-19,42-44,61-63,69H,5-6,13-16,20-24H2,1-4H3,(H,51,57)(H,65,66)/t42-,43+,44-,50-/m0/s1
• InChIKey: FWZXQYUFOHOISC-UUENOOSASA-N
• SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OCN(CCS(=O)(=O)C)C(=O)OCC6=CC(=C(C=C6)O[C]7C([C](C(C(O7)C(=O)O)O)O)O)NC(=O)CN(C)C(=O)CCN8C(=O)C=CC8=O

MAC glucuronide phenol-linked SN-38 (Cat No.:I018025) is a prodrug consisting of a glucuronide and a phenol linker conjugated to SN-38, the active metabolite of irinotecan. The conjugation of the glucuronide and phenol linker to SN-38 improves its solubility and pharmacokinetic properties, resulting in increased efficacy and reduced toxicity compared to irinotecan.

Reference

[1]. Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072.