Macelignan

• CAT Number: I000346
• CAS Number: 107534-93-0
• Molecular Formula: C20H24O4
• Molecular Weight: 328.4
• Purity: ≥95%
• Target: COX
• Solubility: DMSO:43 mg/mL
• Storage: Store at -20℃
• IUPAC Name: 4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol
• InChI: InChI=1S/C20H24O4/c1-13(8-15-4-6-17(21)19(10-15)22-3)14(2)9-16-5-7-18-20(11-16)24-12-23-18/h4-7,10-11,13-14,21H,8-9,12H2,1-3H3/t13-,14+/m0/s1
• InChIKey: QDDILOVMGWUNGD-UONOGXRCSA-N
• SMILES: CC(CC1=CC2=C(C=C1)OCO2)C(C)CC3=CC(=C(C=C3)O)OC

Macelignan (Cat.No:I000346) is a natural compound isolated from Myristica fragrans, commonly known as nutmeg. It possesses various biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Macelignan has shown potential in inhibiting tumor growth and inducing cell apoptosis. It is also being investigated for its potential in neuroprotective and cardiovascular health benefits.

Reference

[1]. Jin DQ, et al. Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture of rat microglial cells. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1264-9.
[2]. Yanti, et al. In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria. Phytother Res. 2008 Mar;22(3):308-12.
[3]. Sohn JH, et al. Protective Effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation. Biol Pharm Bull. 2008 Feb;31(2):273-7.
[4]. Cui CA, et al. Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats. Neurosci Lett. 2008 Dec 19;448(1):110-4.