mAChR antagonist 1

• CAT Number: I040578
• CAS Number: 101491-79-6
• Molecular Formula: C19H22N2O2
• Molecular Weight: 310.39
• Purity: ≥95%
• Synonyms: (1-methylpiperidin-4-yl) N,N-diphenylcarbamate
• InChI: InChI=1S/C19H22N2O2/c1-20-14-12-18(13-15-20)23-19(22)21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3
• InChIKey: RQDLDNLBJUDOFV-UHFFFAOYSA-N
• SMILES: CN1CCC(CC1)OC(=O)N(C2=CC=CC=C2)C3=CC=CC=C3

mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively[1].

Reference

[1]. Marlon Millard, et al. Design, synthesis and preclinical evaluation of muscarine receptor antagonists via a scaffold-hopping approach. Eur J Med Chem. 2023 Oct 21:262:115891.
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