Mad1 (6-21)

For research use only. Not for therapeutic Use.

  • CAT Number: I044202
  • CAS Number: 880150-82-3
  • Molecular Formula: C84H140N24O26S2
  • Molecular Weight: 1966.29
  • Purity: ≥95%
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Mad1 (6-21) is the 6-21 fragment of Mad1 protein. Mad1 (6-21) binds to mammalian Sin3A PAH2 with a Kd of ~29 nM[1].
The PAH2 domain of mSin3A adopts a left-handed, up-and-down, four-helix bundle structure with residues in all four helices as well as in the turn regions defining a compact structural domain with an extensive hydrophobic core. Helices α1 and α2 form a deep hydrophobic pocket, which constitutes the primary interaction surface for the Mad1 (6-21) peptide. The Mad1 (6-21) forms an amphipathic α helix in the complex and interacts with PAH2 mainly through the apolar surface of the helix[1].


Catalog Number I044202
CAS Number 880150-82-3
Molecular Formula C84H140N24O26S2
Purity ≥95%
Reference

[1]. K Brubaker, et al. Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex. Cell. 2000 Nov 10;103(4):655-65.
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