Mafenide Acetate

• CAT Number: I001153
• CAS Number: 13009-99-9
• Molecular Formula: C9H14N2O4S
• Molecular Weight: 246.28
• Purity: ≥95%
• Target: Bacterial
• Solubility: DMSO: ＞ 35 mg/mL
• Storage: Store at -20C
• IUPAC Name: acetic acid;4-(aminomethyl)benzenesulfonamide
• InChI: InChI=1S/C7H10N2O2S.C2H4O2/c8-5-6-1-3-7(4-2-6)12(9,10)11;1-2(3)4/h1-4H,5,8H2,(H2,9,10,11);1H3,(H,3,4)
• InChIKey: UILOTUUZKGTYFQ-UHFFFAOYSA-N
• SMILES: CC(=O)O.C1=CC(=CC=C1CN)S(=O)(=O)N

Mafenide Acetate（Cat No.:I001153）is a topical antimicrobial agent primarily used to prevent and treat infections in severe burn wounds. It works by inhibiting bacterial folic acid synthesis, which disrupts bacterial growth and replication, making it effective against a range of gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa. Mafenide Acetate penetrates burn eschar well, providing effective bacterial control even in deep tissues. Its use in burn care reduces the risk of infection-related complications, promoting wound healing and improving patient outcomes in critical care settings.

Reference

[1]. Siuda, J.F. and C.D. Cihonski, New compounds: carbamate derivatives of mafenide (homosulfanilamide). J Pharm Sci, 1972. 61(11): p. 1856-7.
[2]. Haynes, B.W., Jr., Mafenide acetate in burn treatment. N Engl J Med, 1971. 284(23): p. 1324.
[3]. Haik, J., et al., Burn care standards in Israel: lack of consensus. Burns, 2005. 31(7): p. 845-9.