Mafenide hydrochloride

• CAT Number: I001480
• CAS Number: 138-37-4
• Molecular Formula: C7H11ClN2O2S
• Molecular Weight: 222.69
• Purity: ≥95%
• Target: Antibacterial
• Solubility: 10 mM in H2O
• Storage: Store at -20°C
• IUPAC Name: 4-(aminomethyl)benzenesulfonamide;hydrochloride
• InChI: InChI=1S/C7H10N2O2S.ClH/c8-5-6-1-3-7(4-2-6)12(9,10)11;/h1-4H,5,8H2,(H2,9,10,11);1H
• InChIKey: SIACJRVYIPXFKS-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CN)S(=O)(=O)N.Cl

Mafenide Hydrochloride（Cat No.:I001480）is a sulfonamide antibiotic primarily used as a topical agent for preventing bacterial infections in severe burn wounds. By inhibiting dihydropteroate synthase, it disrupts folic acid synthesis in bacteria, which is crucial for bacterial growth and replication. Known for its effectiveness against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa, Mafenide Hydrochloride is valuable in preventing and treating wound infections in burn patients. Its role in infection control has made it a key treatment in burn care, helping reduce infection-related complications and improve healing outcomes.

Reference

[1]. Siuda, J.F. and C.D. Cihonski, New compounds: carbamate derivatives of mafenide (homosulfanilamide). J Pharm Sci, 1972. 61(11): p. 1856-7.

[2]. Haynes, B.W., Jr., Mafenide acetate in burn treatment. N Engl J Med, 1971. 284(23): p. 1324.

[3]. Haik, J., et al., Burn care standards in Israel: lack of consensus. Burns, 2005. 31(7): p. 845-9.